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List of Icd-9 Codes 240–279: Endocrine, Nutritional and Metabolic Diseases, And Immunity Disorders Information

List of ICD-9 codes 240–279: endocrine, nutritional and metabolic diseases, and immunity disorders

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Contents

3. Endocrine, nutritional and metabolic diseases, and immunity disorders (240–279)

Disorders of thyroid gland (240–246)

Diseases of other endocrine glands (249–259)

Nutritional deficiencies (260–269)

Other metabolic and immunity disorders (270–279)

Disorders of amino-acid transport and metabolism

Disorders of carbohydrate transport and metabolism

Disorders of lipoid metabolism

Disorders of plasma protein metabolism

Gout

Disorders of mineral metabolism

Disorders of fluid, electrolyte, and acid-base balance

Other and unspecified disorders of metabolism

Obesity and other hyperalimentation

Disorders involving the immune mechanism

See also

Pathology: Medical conditions and ICD code
(Disease / Disorder / Illness, Syndrome / Sequence, Symptom / Sign, Injury, etc.)
(A/B, 001–139) Infectious disease/Infection: Bacterial disease (G+, G-) · Virus disease · Parasitic disease (Protozoan infection, Helminthiasis, Ectoparasitic infestation) · Mycosis · Zoonosis
(C/D, 140–239 & 279–289)
Cancer (C00–D48, 140–239) Tumor
Myeloid hematologic (D50–D77, 280–289) Anemia · Coagulopathy
Lymphoid immune (D80–D89, 279) Immunodeficiency · Immunoproliferative disorder · Hypersensitivity
(E, 240–278) Endocrine disease · Nutrition disorder · Inborn error of metabolism
(F, 290–319) Mental disorder
(G, 320–359) Nervous system disease (CNS, PNS) · Neuromuscular disease
(H, 360–389) Eye disease · Ear disease
(I, 390–459) Cardiovascular disease (Heart disease, Vascular disease)
(J, 460–519) Respiratory disease (Obstructive lung disease, Restrictive lung disease, Pneumonia)
(K, 520–579) Stomatognathic disease (Tooth disease) · Digestive disease (Esophageal, Stomach, Enteropathy, Liver, Pancreatic)
(L, 680–709) Skin disease · skin appendages (Nail disease, Hair disease, Sweat gland disease)
(M, 710–739) Musculoskeletal disorders: Myopathy · Arthropathy · Osteochondropathy (Osteopathy, Chondropathy)
(N, 580–629) Urologic disease (Nephropathy, Urinary bladder disease) · Male genital disease · Breast disease · Female genital disease
(O, 630–679) Complications of pregnancy · Obstetric labor complication · Puerperal disorder
(P, 760–779) Fetal disease
(Q, 740–759) Congenital disorder (Congenital abnormality)
(R, 780–799) Syndromes · Medical signs (Eponymous)
(S/T, 800–999) Bone fracture · Joint dislocation · Sprain · Strain · Subluxation · Head injury · Chest trauma · Poisoning
Endocrine pathology: endocrine diseases (E00–E35, 240–259)
Pancreas/ glucose metabolism
Hypofunction Diabetes mellitus types: (type 1, type 2, MODY 1 2 3 4 5 6) · complications (coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy, cardiomyopathy) insulin receptor (Rabson–Mendenhall syndrome) · Insulin resistance
Hyperfunction Hypoglycemia · beta cell (Hyperinsulinism) · G cell (Zollinger–Ellison syndrome)
Hypothalamic/ pituitary axes
Hypothalamus gonadotropin (Kallmann syndrome, Adiposogenital dystrophy) · CRH (Tertiary adrenal insufficiency) · vasopressin (Neurogenic diabetes insipidus) · general (Hypothalamic hamartoma)
Pituitary
Hyperpituitarism anterior (Acromegaly, Hyperprolactinaemia, Pituitary ACTH hypersecretion) · posterior (SIADH) · general (Nelson's syndrome)
Hypopituitarism anterior (Kallmann syndrome, Growth hormone deficiency, ACTH deficiency/Secondary adrenal insufficiency) · posterior (Neurogenic diabetes insipidus) · general (Empty sella syndrome, Pituitary apoplexy, Sheehan's syndrome, Lymphocytic hypophysitis)
Thyroid
Hypothyroidism Iodine deficiency · Cretinism (Congenital hypothyroidism) · Myxedema · Euthyroid sick syndrome
Hyperthyroidism Hyperthyroxinemia (Thyroid hormone resistance, Familial dysalbuminemic hyperthyroxinemia) · Hashitoxicosis · Thyrotoxicosis factitia · Graves' disease
Thyroiditis Acute infectious · Subacute (De Quervain's, Subacute lymphocytic) · Autoimmune/chronic (Hashimoto's, Postpartum, Riedel's)
Goitre Endemic goitre · Toxic nodular goitre · Toxic multinodular goiter Thyroid nodule
Parathyroid
Hypoparathyroidism Pseudohypoparathyroidism
Hyperparathyroidism Primary · Secondary · Tertiary · Osteitis fibrosa cystica
Adrenal
Hyperfunction aldosterone: Hyperaldosteronism/Primary aldosteronism (Conn syndrome, Bartter syndrome, Glucocorticoid remediable aldosteronism) · AME · Liddle's syndrome · 17α CAH cortisol: Cushing's syndrome (Pseudo-Cushing's syndrome) sex hormones: 21α CAH · 11β CAH
Hypofunction/ Adrenal insufficiency (Addison's, WF) aldosterone: Hypoaldosteronism (21α CAH, 11β CAH) cortisol: CAH (Lipoid, 3β, 11β, 17α, 21α) sex hormones: 17α CAH
Gonads ovarian: Polycystic ovary syndrome · Premature ovarian failure testicular: enzymatic (5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency) · Androgen receptor (Androgen insensitivity syndrome) general: Hypogonadism (Delayed puberty) · Hypergonadism (Precocious puberty)
Height Gigantism · Dwarfism/Short stature (Laron syndrome, Psychosocial)
Multiple Autoimmune polyendocrine syndrome (APS1, APS2) · Carcinoid syndrome · Multiple endocrine neoplasia (1, 2A, 2B) · Progeria (Werner syndrome, Acrogeria, Metageria) · Woodhouse-Sakati syndrome

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Nutrition disorders (E40–E68, 260–269)
Hypoalimentation/ malnutrition
Protein-energy malnutrition Kwashiorkor · Marasmus · Catabolysis
Avitaminosis
B vitamins B1: Beriberi/Wernicke's encephalopathy (Thiamine deficiency) · B2: Ariboflavinosis · B3: Pellagra (Niacin deficiency) · B6: Pyridoxine deficiency · B7: Biotin deficiency · B9: Folate deficiency · B12: Vitamin B12 deficiency
Other vitamins A: Vitamin A deficiency/Bitot's spots · C: Scurvy · D: Hypovitaminosis D/Rickets/Osteomalacia · E: Vitamin E deficiency · K: Vitamin K deficiency
Mineral deficiency Sodium · Potassium · Magnesium · Calcium · Iron · Zinc · Manganese · Copper · Iodine · Chromium · Molybdenum · Selenium (Keshan disease)
Hyperalimentation
Overweight · Obesity Childhood obesity · Obesity hypoventilation syndrome · Abdominal obesity
Vitamin poisoning Hypervitaminosis A · Hypervitaminosis D · Hypervitaminosis E
Mineral overload see inborn errors of metal metabolism, toxicity

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Inborn error of amino acid metabolism (E70–E72, 270)
K→acetyl-CoA
Lysine/straight chain Glutaric acidemia type 1 · type 2 · Hyperlysinemia · Pipecolic acidemia · Saccharopinuria
Leucine Maple syrup urine disease · Isovaleric acidemia · 3-Methylcrotonyl-CoA carboxylase deficiency · 3-hydroxy-3-methylglutaryl-CoA lyase deficiency · 3-Methylglutaconic aciduria 1
Tryptophan Hypertryptophanemia
G
G→pyruvate→citrate
Glycine Sarcosinemia · D-Glyceric acidemia · Glutathione synthetase deficiency Glycine→Creatine: GAMT deficiency · Glycine encephalopathy
G→glutamate→ α-ketoglutarate
Histidine Carnosinemia · Histidinemia · Urocanic aciduria
Proline Hyperprolinemia · Prolidase deficiency
Glutamate/glutamine SSADHD
G→propionyl-CoA→ succinyl-CoA
Valine Maple syrup urine disease · Hypervalinemia · Isobutyryl-CoA dehydrogenase deficiency
Isoleucine Maple syrup urine disease · Beta-ketothiolase deficiency · 2-Methylbutyryl-CoA dehydrogenase deficiency
Methionine Hypermethioninemia · Homocystinuria · Cystathioninuria
General BC/OA Propionic acidemia · Methylmalonic acidemia · Methylmalonyl-CoA mutase deficiency
G→fumarate
Phenylalanine/tyrosine
Phenylketonuria Tetrahydrobiopterin deficiency · 6-Pyruvoyltetrahydropterin synthase deficiency
Tyrosinemia Type II tyrosinemia · Type III tyrosinemia/Hawkinsinuria · Alkaptonuria/Ochronosis · Type I tyrosinemia
Tyrosine→Melanin Albinism: Ocular albinism (1) · Oculocutaneous albinism (Hermansky–Pudlak syndrome) · Waardenburg syndrome
Tyrosine→Norepinephrine Dopamine beta hydroxylase deficiency · reverse: Brunner syndrome
G→oxaloacetate
Urea cycle/Hyperammonemia (arginine, aspartate) N-Acetylglutamate synthase deficiency · Carbamoyl phosphate synthetase I deficiency · Ornithine transcarbamylase deficiency/translocase deficiency · Citrullinemia · Argininosuccinic aciduria · Argininemia
Transport/ IE of RTT Solute carrier family: Cystinuria · Hartnup disease · Lysinuric protein intolerance · Iminoglycinuria Fanconi syndrome: Oculocerebrorenal syndrome · Cystinosis
Other Trimethylaminuria · 2-Hydroxyglutaric aciduria · Fumarase deficiency

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Inborn error of carbohydrate metabolism: monosaccharide metabolism disorders (including glycogen storage diseases) (E73–E74, 271)
Sucrose, transport (extracellular)
Disaccharide catabolism Lactose intolerance · Sucrose intolerance
Monosaccharide transport Glucose-galactose malabsorption · Inborn errors of renal tubular transport (Renal glycosuria) · Fructose malabsorption
Hexose → glucose
Monosaccharide catabolism fructose: Essential fructosuria · Fructose intolerance galactose/galactosemia : GALK deficiency · GALT deficiency/GALE deficiency
Glucose ⇄ glycogen
Glycogenesis GSD type 0, glycogen synthase · GSD type IV, Andersen's, branching
Glycogenolysis extralysosomal: GSD type V, McArdle, muscle glycogen phosphorylase/GSD type VI, Hers', liver glycogen phosphorylase · GSD type III, Cori's, debranching lysosomal/LSD: GSD type II, Pompe's, glucosidase
Glucose ⇄ CAC
Glycolysis MODY 2/HHF3 · GSD type VII, Tarui's, phosphofructokinase · Triosephosphate isomerase deficiency · Pyruvate kinase deficiency
Gluconeogenesis PCD · Fructose bisphosphatase deficiency · GSD type I, von Gierke, glucose 6-phosphatase
Pentose phosphate pathway Glucose-6-phosphate dehydrogenase deficiency · Transaldolase deficiency
Other Hyperoxaluria (Primary hyperoxaluria) · Pentosuria

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Inborn error of lipid metabolism: dyslipidemia (E78, 272.0–272.6)
Hyperlipidemia Hypercholesterolemia/Hypertriglyceridemia (Lipoprotein lipase deficiency/Type Ia, Familial apoprotein CII deficiency/Type Ib, Familial hypercholesterolemia/Type IIa, Combined hyperlipidemia/Type IIb, Familial dysbetalipoproteinemia/Type III, Familial hypertriglyceridemia/Type IV) · Xanthoma/Xanthomatosis
Hypolipoproteinemia
Hypoalphalipoproteinemia/HDL Lecithin cholesterol acyltransferase deficiency · Tangier disease
Hypobetalipoproteinemia/LDL Abetalipoproteinemia · Apolipoprotein B deficiency · Chylomicron retention disease
Lipodystrophy Barraquer–Simons syndrome
Other Lipomatosis · Adiposis dolorosa · Lipoid proteinosis · APOA1 familial renal amyloidosis

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(LSD) Inborn error of carbohydrate metabolism: glycoproteinosis (E77, 271.8)
Anabolism Dolichol kinase deficiency · Congenital disorder of glycosylation
Post-translational modification of lysosomal enzymes Mucolipidosis: I-cell disease/II · Pseudo-Hurler polydystrophy/III
Catabolism Aspartylglucosaminuria · Fucosidosis · mannosidosis (Alpha-mannosidosis, Beta-mannosidosis) · Sialidosis · Schindler disease
Other solute carrier family (Salla disease) · Galactosialidosis

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(LSD) Inborn error of lipid metabolism: lipid storage disorders (E75, 272.7–272.8)
Sphingolipidoses (to ceramide)
From ganglioside (gangliosidoses) Ganglioside: GM1 gangliosidoses · GM2 gangliosidoses (Sandhoff disease, Tay–Sachs disease, AB variant)
From globoside Globotriaosylceramide: Fabry's disease
From sphingomyelin Sphingomyelin: phospholipid: Niemann–Pick disease (SMPD1-associated, type C) Glucocerebroside: Gaucher's disease
From sulfatide (sulfatidoses, leukodystrophy) Sulfatide: Metachromatic leukodystrophy · Multiple sulfatase deficiency Galactocerebroside: Krabbe disease
To sphingosine Ceramide: Farber disease
NCL Infantile · Jansky-Bielschowsky disease · Batten disease
Other Cerebrotendineous xanthomatosis · Cholesteryl ester storage disease (Lysosomal acid lipase deficiency/Wolman disease) · Sea-blue histiocyte syndrome

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Immune disorders, Immunoproliferative immunoglobulin disorders (D89, 273)
PCDs/PP Plasmacytoma · Multiple myeloma (Plasma cell leukemia) · MGUS · IgM (Macroglobulinemia/Waldenström's macroglobulinemia) · heavy chain (Heavy chain disease) · light chain (Primary amyloidosis)
Other hypergammaglobulinemia Cryoglobulinemia

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Inborn error of metal metabolism (E83, 275)
Transition metal
Fe high: Primary iron overload disorder: Hemochromatosis/HFE1 · Juvenile/HFE2 · HFE3 · African iron overload/HFE4 · Aceruloplasminemia · Atransferrinemia · Hemosiderosis deficiency: Iron deficiency
Cu high: Copper toxicity · Wilson's disease deficiency: Copper deficiency · Menkes disease/Occipital horn syndrome
Zn high: Zinc toxicity deficiency: Acrodermatitis enteropathica
Electrolyte
Na+ and K+ see
PO43− high: Hyperphosphatemia deficiency: Hypophosphatemia · alkaline phosphatase (Hypophosphatasia)
Mg2+ high: Hypermagnesemia deficiency: Hypomagnesemia
Ca2+ high: Hypercalcaemia · Milk-alkali syndrome (Burnett's) · Calcinosis (Calciphylaxis, Calcinosis cutis) · Calcification (Metastatic calcification, Dystrophic calcification) · Familial hypocalciuric hypercalcemia deficiency: Hypocalcaemia · Osteomalacia · Pseudohypoparathyroidism (Albright's hereditary osteodystrophy) · Pseudopseudohypoparathyroidism

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Water-electrolyte imbalance and acid-base imbalance (E86–E87, 276)
Volume status Volume contraction (Dehydration/Hypovolemia) · Hypervolemia
Electrolyte
Na+ Hypernatremia · Hyponatremia (Hypotonic, Isotonic)
K+ Hyperkalemia · Hypokalemia
Cl− Hyperchloremia · Hypochloremia
Acid-base
Acidosis Metabolic: High anion gap (Ketoacidosis/Diabetic ketoacidosis, Lactic) · Normal anion gap (Hyperchloremic, Renal tubular) Respiratory
Alkalosis Metabolic: Contraction alkalosis Respiratory
Both Mixed disorder of acid-base balance

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Inborn error of purine-pyrimidine metabolism (E79, 277.2)
Purine metabolism
Anabolism Adenylosuccinate lyase deficiency · Adenosine Monophosphate Deaminase Deficiency type 1
Nucleotide salvage Lesch-Nyhan syndrome/Hyperuricemia · Adenine phosphoribosyltransferase deficiency
Catabolism Adenosine deaminase deficiency · Purine nucleoside phosphorylase deficiency · Xanthinuria · Gout · Mitochondrial neurogastrointestinal encephalopathy syndrome
Pyrimidine metabolism
Anabolism Orotic aciduria · Miller syndrome
Catabolism Dihydropyrimidine dehydrogenase deficiency

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Heme metabolism disorders (E80, 277.1, 277.4)
Porphyria, hepatic and erythropoietic (porphyrin) early mitochondrial: ALAD porphyria · Acute intermittent porphyria cytoplasmic: Gunther disease/congenital erythropoietic porphyria · Porphyria cutanea tarda/Hepatoerythropoietic porphyria late mitochondrial: Hereditary coproporphyria · Variegate porphyria · Erythropoietic protoporphyria
Hereditary hyperbilirubinemia (bilirubin) unconjugated: Gilbert's syndrome · Crigler-Najjar syndrome · Lucey-Driscoll syndrome conjugated: Dubin–Johnson syndrome · Rotor syndrome

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Metabolic disease: amyloidosis (E85, 277.3)
Common amyloid forming proteins
Systemic amyloidosis
Organ-limited amyloidosis
Heart AANF/Isolated atrial amyloidosis
Brain
Kidney
Cutaneous
Endocrine
Thyroid
ACal/Medullary thyroid cancer
Pituitary
APro/Prolactinoma
Pancreas
AIAPP/Insulinoma
AIAPP/Diabetes mellitus type 2
(LSD) Inborn error of carbohydrate metabolism: mucopolysaccharidosis (E76, 277.5)
Anabolism

Pentosuria

Heparin sulfate: EXT1 (Hereditary multiple exostoses 1)

Chondroitin sulfate: PAPSS2 (Spondyloepimetaphyseal dysplasia, Pakistani type)
Catabolism IDUA (1:Hurler/Scheie) · IDS (2:Hunter) · SGSH/NAGLU/HGSNAT/GNS (3:Sanfilippo ABCD) · GALNS/GLB1 (4:Morquio) · ARSB (6:Maroteaux-Lamy) · GUSB (7:Sly)

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Inborn error of lipid metabolism: fatty-acid metabolism disorders (E71.3, 277.81–277.85)
Synthesis Biotinidase deficiency
Degradation
Acyl transport Carnitine (Primary, I, II, -acylcarnitine) · Adrenoleukodystrophy
Beta oxidation
General Acyl CoA dehydrogenase (Short-chain, Medium-chain, Long-chain 3-hydroxy, Very long-chain) Mitochondrial trifunctional protein deficiency: Acute fatty liver of pregnancy
Unsaturated 2,4 Dienoyl-CoA reductase deficiency
Odd chain Propionic acidemia
Other 3-hydroxyacyl-coenzyme A dehydrogenase deficiency
To acetyl-CoA Malonic aciduria
Aldehyde Sjögren–Larsson syndrome

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Genetic disorder, organelle: Peroxisomal disorders and lysosomal structural disorders (E80.3, 277.86)
Peroxisome biogenesis disorder Zellweger syndrome · Autosomal adrenoleukodystrophy · Infantile Refsum disease · Adult Refsum disease-2 · RCP 1
Enzyme-related Acatalasia · RCP 2&3 · Mevalonate kinase deficiency · D-bifunctional protein deficiency · Adult Refsum disease-1
Transporter-related X-linked adrenoleukodystrophy/Adrenomyeloneuropathy
Lysosomal Danon disease
See also: , structural (, , , , , ) · DNA/RNA/protein synthesis (, , , ) · membrane (, , , , ) · transduction (, , ),
Non-Mendelian inheritance: Mitochondrial diseases (277.87)
Carbohydrate metabolism PCD · PDHA
Primarily nervous system LHON · NARP · Leigh's
Myopathies Mitochondrial encephalomyopathy (MELAS, MERRF) · KSS · PEO
No primary system DAD · MNGIE · Pearson syndrome
Chromosomal TIMM8A (Mohr-Tranebjaerg syndrome) · OPA1 (Kjer's optic neuropathy)
see also structural (, , , , , ) · DNA/RNA/protein synthesis (, , , ) · membrane (, , , , ) · transduction (, , ),
Histiocytosis (D76.0, 277.89)
WHO-I/Langerhans cell histiocytosis/ X-type histiocytosis Letterer–Siwe disease · Hand–Schüller–Christian disease · Eosinophilic granuloma · Congenital self-healing reticulohistiocytosis
WHO-II/non-Langerhans cell histiocytosis/ Non-X histiocytosis Juvenile xanthogranuloma · Hemophagocytic lymphohistiocytosis · Erdheim-Chester disease · Niemann-Pick disease · Sea-blue histiocyte syndrome · Benign cephalic histiocytosis · Generalized eruptive histiocytoma · Xanthoma disseminatum · Progressive nodular histiocytosis · Papular xanthoma · Hereditary progressive mucinous histiocytosis · Reticulohistiocytosis (Multicentric reticulohistiocytosis, Reticulohistiocytoma) · Indeterminate cell histiocytosis
WHO-III/malignant histiocytosis Histiocytic sarcoma · Langerhans cell sarcoma · Interdigitating dendritic cell sarcoma · Follicular dendritic cell sarcoma
Ungrouped Rosai–Dorfman disease

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Immune disorders: Lymphoid and complement immunodeficiency (D80–D85, 279.0–4)
Primary
Antibody/humoral (B)
Hypogammaglobulinemia X-linked agammaglobulinemia · Transient hypogammaglobulinemia of infancy
Dysgammaglobulinemia IgA deficiency · IgG deficiency · IgM deficiency · Hyper IgM syndrome (2, 3, 4, 5) · Wiskott-Aldrich syndrome · Hyper-IgE syndrome
Other Common variable immunodeficiency · ICF syndrome
T cell deficiency (T) thymic hypoplasia: hypoparathyroid (Di George's syndrome) · euparathyroid (Nezelof syndrome, Ataxia telangiectasia) peripheral: Purine nucleoside phosphorylase deficiency · Hyper IgM syndrome (1)
Severe combined (B+T) x-linked: X-SCID autosomal: Adenosine deaminase deficiency · Omenn syndrome · ZAP70 deficiency · Bare lymphocyte syndrome
Acquired AIDS
Leukopenia: Lymphocytopenia Idiopathic CD4+ lymphocytopenia
Complement deficiency C1-inhibitor (Angioedema/Hereditary angioedema) · Complement 2 deficiency/Complement 4 deficiency · MBL deficiency · Properdin deficiency · Complement 3 deficiency · Terminal complement pathway deficiency · Paroxysmal nocturnal hemoglobinuria · Complement receptor deficiency

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Other metabolic pathology / Inborn error of metabolism (E70–E90, 270–279)
Other Aldolase A deficiency · Alpha 1-antitrypsin deficiency · Cystic fibrosis · Acatalasia · Tumor lysis syndrome

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